摘要
目的 研究铁杆蒿三氯甲烷、乙酸乙酯提取物的化学成分。方法 采用硅胶和LH-20葡聚糖凝胶柱色谱法和半制备高效色相色谱法对铁杆蒿三氯甲烷、乙酸乙酯提取物进行分离,运用各种波谱法鉴定分离所得化合物的结构式。结果 鉴定了13个化合物: 5-羟基-7,4′-二甲氧基黄酮(1);4-羟基-苯乙酮(2);5,4′-二羟基-7,3′-二甲氧基黄酮(3);5,7-二羟基-6,4′-二甲氧基黄酮(4);5,7-二羟基-4′-甲氧基黄酮(5);5,4′-二羟基-7-甲氧基黄酮(6);咖啡酸(7);8-羟基-6,7-二甲氧基香豆素(8);3,4-二羟基-苯甲酸(9);苯乙酮-4-O-β-D-葡萄糖苷(10);6-甲氧基香豆素-7-O-β-D-葡萄糖苷(11);6,8-二甲氧基香豆素-7-O-β-D-葡萄糖苷(12);2-羟基-6-甲氧基苯乙酮-4-O-β-D-葡萄糖苷(13)。结论 化合物3, 4, 5, 9,10, 12均为首次从该植物中分得。
Abstract
OBJECTIVE To study the chemical constituents of the chloroform extract from the aerial parts of Artemisa sacrorum. METHODS The chemical constituents were isolated and purified by silica gel and LH-20 column chromatography and preparation HPLC. Their structures were identified by spectral analysis methods. RESULTS Thirteen compounds were obtained and identified as 5-hydroxyl-7,4′-dimethoxyflavone(1), 4-hydroxylacetophenone(2), 5,4′-dihydroxyl-7,3′-dimethoxyflavone(3), 5,7-dihydroxyl-6,4′-dimethoxyflavone(4), 5,7-dihydroxyl-4′-methoxyflavone(5), 5,4′-dihydroxyl-7-methoxyflavone(6), caffeic acid(7), 8-hydroxyl-6,7-dimethoxycoumarin(8), 3,4-dihydroxylbenzoic acid(9), acetophenone-4-O-β-D-glucoside(10), 6-methoxycoumarin-7-O-β-D-glucoside(11), 6,8-dimethoxycoumarin-7-O-β-D-glucoside(12), and 2-hydroxyl-6-methoxyacetophenone-4-O-β-D-glucoside(13). CONCLUSION Compounds 3, 4, 5, 9, 10 and 12 are isolated from this plant for the first time.
关键词
铁杆蒿 /
黄酮 /
香豆素 /
苯丙酮 /
5 /
4′-二羟基-7 /
3′-二甲氧基黄酮 /
5 /
7-二羟基-6 /
4′-二甲氧基黄酮 /
5 /
7-二羟基-4′-甲氧基黄酮
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Key words
Artemisa sacrorum. /
flavone /
coumarin /
acetophenone /
5,4′-dihydroxyl-7,3′-dimethoxyflavone /
5,7-dihydroxyl-6,4′-dimethoxyflavone /
5,7-dihydroxyl-4′-methoxyflavone
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王青虎,吴荣君,齐格奇,吴杰斯,代那音台,那仁朝克图.
蒙药铁杆蒿化学成分研究[J]. 中国药学杂志, 2015, 50(16): 1380-1384 https://doi.org/10.11669/cpj.2015.16.004
WANG Qing-hu, WU Rong-jun, QI Ge-qi, WU Jie-si, DAI Na-yin-tai, Na-ren-chao-ke-tu.
Chemical Constituents of Artemisa sacrorum Ledeb[J]. Chinese Pharmaceutical Journal, 2015, 50(16): 1380-1384 https://doi.org/10.11669/cpj.2015.16.004
中图分类号：
R284
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参考文献
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脚注
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基金
国家自然科学基金资助项目(81460654);2014年度研究生科研创新资助项目(NMDSS1433)
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